NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: Curcumin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

jun proto-oncogene

Prostate Cancer

DU-145

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-

-

-

Curcumin completely suppressed AP-1 in DU145 cells at around 50 µM.

jun proto-oncogene

Prostate Cancer

LNCaP

-

-

-

-

Transcriptional activities of AP-1 and NF-kB were significantly decreased by the treatment with maximum non-toxic doses of curcumin

jun proto-oncogene

Prostate Cancer

PC-3

-

-

-

-

Transcriptional activities of AP-1 and NF-kB were significantly decreased by the treatment with maximum non-toxic doses of curcumin

jun proto-oncogene

Human promyelocytic leukemia

HL-60

-

-

-

-

When the HL-60 cells were preincubated with various concentrations of curcumin, TPA induced activation of AP-1 was inhibited in a concentration dependent manner. An almost complete inhibition of AP-1 activation was achieved with curcumin at a concentration as low as 1 µM.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.