NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Deguelin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Human promyelocytic leukemiaHL-60----P-Akt protein level in HL-60 cells was reduced after 24-48 h treatment with deguelin at the concentrations of 20.14 nM. This indicates that deguelin promotes P-Akt protein degradation in HL-60 cells in a time-dependent manner.19455392
BCL2B-cell CLL/lymphoma 2596Human promyelocytic leukemiaHL-60----After treated with 20.14 µM deguelin for 24, 48 h, the expression of Bcl-2 was down-regulated dramatically in a time-dependent manner.19455392
birc5abaculoviral IAP repeat-containing 5a373110Human promyelocytic leukemiaHL-60----After treated with 20.14 µM deguelin for 24, 48 h, the expression of survivin was down-regulated dramatically in a time-dependent manner.19455392
birc5abaculoviral IAP repeat-containing 5a373110Adult T-cell leukemia (ATL) KUT-1----Deguelin treatment for 24 h reduced the protein level of survivin. These results suggest that cell death of KUT-1 cells by deguelin is induced in part via the down-regulation of survivin expression.19781773
birc5abaculoviral IAP repeat-containing 5a373110Adult T-cell leukemia (ATL) MT-2----Deguelin treatment for 24 h reduced the protein level of survivin. These results suggest that cell death of MT-2 cells by deguelin is induced in part via the down-regulation of survivin expression.19781773
CASP3caspase 3, apoptosis-related cysteine peptidase836Adult T-cell leukemia (ATL) KUT-1----Caspase-3 was cleaved after treatment of KUT-1 cells with deguelin for at least 24 h, suggesting that deguelin induces cell death of these cells, at least in part via the apoptosis pathway involving caspase-3.19781773
CASP3caspase 3, apoptosis-related cysteine peptidase836Adult T-cell leukemia (ATL) MT-2----Caspase-3 was cleaved after treatment of MT-2 cells with deguelin for at least 24 h, suggesting that deguelin induces cell death of these cells, at least in part via the apoptosis pathway involving caspase-3.19781773
HSPA4heat shock 70kDa protein 43308Adult T-cell leukemia (ATL) KUT-1----Deguelin upregulated Hsp70 expression as well as 17-DMAG(Hsp90 inhibitor). These results suggested that deguelin acts as Hsp90 inhibitor in KUT-1 cells.19781773
HSPA4heat shock 70kDa protein 43308Adult T-cell leukemia (ATL) MT-2----Deguelin upregulated Hsp70 expression as well as 17-DMAG(Hsp90 inhibitor). These results suggested that deguelin acts as Hsp90 inhibitor in MT-2 cells.19781773
PARP1poly (ADP-ribose) polymerase 1142Adult T-cell leukemia (ATL) KUT-1----PARP was cleaved after treatment of KUT-1 cells with deguelin for at least 24 h, suggesting that deguelin induces cell death of these cells.19781773
PARP1poly (ADP-ribose) polymerase 1142Adult T-cell leukemia (ATL) MT-2----PARP was cleaved after treatment of MT-2 cells with deguelin for at least 24 h, suggesting that deguelin induces cell death of these cells.19781773
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774Adult T-cell leukemia (ATL) KUT-1----STAT3 phosphorylationwas suppressed at 6-9 h, after treatment of KUT-1 andMT-2 cellswith deguelin. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells.19781773
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774Adult T-cell leukemia (ATL) MT-2----STAT3 phosphorylationwas suppressed at 6-9 h, after treatment of KUT-1 andMT-2 cellswith deguelin. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells.19781773
STAT5Bsignal transducer and activator of transcription 5B6777Adult T-cell leukemia (ATL) KUT-1----STAT5 phosphorylation was suppressed in KUT-1 but not MT-2 cells. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells.19781773
STAT5Bsignal transducer and activator of transcription 5B6777Adult T-cell leukemia (ATL) MT-2----STAT5 phosphorylation was suppressed in KUT-1 but not MT-2 cells. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells.19781773

 






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