NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Deguelin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774Adult T-cell leukemia (ATL) KUT-1----STAT3 phosphorylationwas suppressed at 6-9 h, after treatment of KUT-1 andMT-2 cellswith deguelin. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells.19781773
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774Adult T-cell leukemia (ATL) MT-2----STAT3 phosphorylationwas suppressed at 6-9 h, after treatment of KUT-1 andMT-2 cellswith deguelin. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells.19781773

 






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