NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: Deguelin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

STAT5B

signal transducer and activator of transcription 5B

6777

Adult T-cell leukemia (ATL)

KUT-1

-

-

-

-

STAT5 phosphorylation was suppressed in KUT-1 but not MT-2 cells. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells.

19781773

STAT5B

signal transducer and activator of transcription 5B

6777

Adult T-cell leukemia (ATL)

MT-2

-

-

-

-

STAT5 phosphorylation was suppressed in KUT-1 but not MT-2 cells. On the other hand, Erk1/2 phosphorylation was not inhibited by deguelin treatment in these cells , indicating the selectivity of deguelin for STAT proteins in KUT-1 and MT-2 cells.

19781773

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.