NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: Deguelin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

birc5a

baculoviral IAP repeat-containing 5a

373110

Human promyelocytic leukemia

HL-60

-

-

-

-

After treated with 20.14 µM deguelin for 24, 48 h, the expression of survivin was down-regulated dramatically in a time-dependent manner.

19455392

birc5a

baculoviral IAP repeat-containing 5a

373110

Adult T-cell leukemia (ATL)

KUT-1

-

-

-

-

Deguelin treatment for 24 h reduced the protein level of survivin. These results suggest that cell death of KUT-1 cells by deguelin is induced in part via the down-regulation of survivin expression.

19781773

birc5a

baculoviral IAP repeat-containing 5a

373110

Adult T-cell leukemia (ATL)

MT-2

-

-

-

-

Deguelin treatment for 24 h reduced the protein level of survivin. These results suggest that cell death of MT-2 cells by deguelin is induced in part via the down-regulation of survivin expression.

19781773

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.