Compound: Ergolide

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

PARP1

poly (ADP-ribose) polymerase 1

142

T cell leukemia

Jurkat T

Treatment with ergolide, a sesquiterpene lactone from Inula britannica var chinensis, caused theinduction of apoptosis in Jurkat T cells, which was confirmed by DNA fragmentation, caspase-3activation and cleavage of poly(ADP-ribose) polymerase in response to ergolide. Furthermore,mitochondrial dysfunction appeared to be associated with ergolide-induced apoptosis, becauseBax translocation and cytochrome c release were stimulated by ergolide. In parallel, the nuclearfactor- B (NF- B) signaling pathway was significantly inhibited by ergolide, which was accompaniedby down-regulation of cell survival molecules, such as X-chromosome-linked inhibitor of apoptosisand Bcl-2.

16354403

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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