NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Eupafolin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CYCScytochrome c54205Cervix AdenocarcinomaHeLa----Levels of cytosolic cytochrome c and Apaf-1 were elevated by eupafolin in HeLa cells, whereas XIAP levels decreased, and thus suggesting the involvement of the mitochondrial pathway in eupafolin-induced apoptosis.Cytosolic cytochrome c activates procaspase-9 by binding to Apaf-1, which leads to caspase-9 activation and the subsequent activations of downstream executioner caspases (caspases-3, -6, and -7).20397191

 






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