NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Fangchinoline

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Breast CarcinomaMDA-MB-231----The results showed that fangchinoline clearly reduced phosphorylated Akt in a concentration-dependent manner indicating that fangchinoline inhibits Akt activitie.22130369
BAXBCL2-associated X protein581Breast CarcinomaMDA-MB-231----The expression of Bax was significantly increase.22130369
BCL2B-cell CLL/lymphoma 2596Breast CarcinomaMDA-MB-231----Expression of Bcl-2 significantly decreased after treatment with fangchinolin.22130369

 






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