NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Gallic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
SULT1A3sulfotransferase family, cytosolic, 1A, phenol-preferring, member 36818HepatomaHep G2----Gallic acid was found to increase PST-P activity. Gallic acid inducing PST-P activity, in a concentration-dependent manner, in concentrations of 10-50 µM, with a maximum of 4-5-fold induction. Gallic acid, a trihydroxybenzoic acid, has been found to cause a significant increase in the activity of PST-P. PST-P mRNA expression was induced markedly by gallic acid, in a dose-responsive manner. A maximum of 4.6-fold mRNA expression was observed at 50 µM. A marked induction of PST-P mRNA expression, by gallic acid, was observed after 6 h of exposure; maximum induction of PST-P mRNA expression was observed at 12 h after the addition of 50 µM gallic acid. PST-P protein was markedly induced by gallic acid, in a dose response manner, at concentrations of 10-50 µM. A maximum of 3.5-fold induction was observed at 50 µM.Significant (p <0.05) induction of PST-P protein was observed 24 h after the addition of 50 µM gallic acid. The enhanced PST-P protein expression in HepG2 cells, after treatment with gallic acid, corresponded to the induction of PST-P activity , suggesting that the observed induction of PST-P activity, by gallic acid, is due to increased PST-P protein synthesis, through activation of gene transcription.15941313

 






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