NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Glabridin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Breast CarcinomaMDA-MB-231----Glabridin also decreased the phosphorylation of FAK/Src downstream kinase, AKT, in breast cancer.20626003
ITGAVintegrin, alpha V3685Breast CarcinomaMDA-MB-231----Overexpression of integrins in malignancy cells contributes to cancer progression and metastasis by increasing tumor cell survival proliferation, migration and invasion. Fow cytometry data also showed that glabridin decreased the expression of integrin Beta3. Glabridin can inhibit integrins, at least for integrin alphav and integrin Beta3, by increasing the degradation of these integrins.20626003
ITGB3integrin, beta 33690Breast CarcinomaMDA-MB-231----Overexpression of integrins in malignancy cells contributes to cancer progression and metastasis by increasing tumor cell survival proliferation, migration and invasion. Fow cytometry data also showed that glabridin decreased the expression of integrin alphav. Glabridin can inhibit integrins, at least for integrin alphav and integrin Beta3, by increasing the degradation of these integrins.20626003
MYLKmyosin light chain kinase4638Breast CarcinomaMDA-MB-231----Glabridin decreased the phosphorylation of MLC in MDA-MB-231. And MLC involved in controlling cell migration. Exposure to glabridin decreased the phosphorylation of MLC at Thr 18/Ser 19.20626003
PTK2PTK2 protein tyrosine kinase 25747Breast CarcinomaMDA-MB-231----FAK is essential for the regulation of integrin-mediated cell adhesion and migration of cancer cells. Glabridin decreased the phosphorylation of FAK at Tyr 397, 576 and 925 sites in both MDA-MB-231 cells.20626003
RHOAras homolog family member A387Breast CarcinomaMDA-MB-231----Aberrant regulation of Rho proteins is associated with metastasis by promoting cancer angiogenesis and tumor cell motility.Glabridin decreased RhoA expression in a time-dependent manner.20626003
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)6714Breast CarcinomaMDA-MB-231----They found that glabridin decreased the phosphorylation of FAK at 397, 576 and 925, and increased inactive phosphorylation Src at Tyr 527. The association of FAK and Src increased in a time-dependent manner in glabridin-treated MDA-MB-231 cells, as detected by immunoprecipitation assay. Glabridin also caused that release of Src from FAK, resulting in the inactivation of FAK/Src complex.20626003

 






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