NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: Glabridin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

integrin, alpha V

Breast Carcinoma

MDA-MB-231

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Overexpression of integrins in malignancy cells contributes to cancer progression and metastasis by increasing tumor cell survival proliferation, migration and invasion. Fow cytometry data also showed that glabridin decreased the expression of integrin Beta3. Glabridin can inhibit integrins, at least for integrin alphav and integrin Beta3, by increasing the degradation of these integrins.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.