NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: Hyperforin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

v-akt murine thymoma viral oncogene homolog 1

Leukemia

U-937

-

-

-

-

HF supppressed the kinase activity of Akt1, and combined treatment with the allosteric Akt1 inhibitor Akt-I-VIII significantly enhanced apoptosis of U937 cell.

caspase 3, apoptosis-related cysteine peptidase

Leukemia

U-937

-

-

-

-

Hyperforin induces apoptosis at least through the activation of caspases-3 in the intrinsic pathway.

caspase 9, apoptosis-related cysteine peptidase

Leukemia

U-937

-

-

-

-

Hyperforin induces apoptosis at least through the activation of caspases-9 in the intrinsic pathway.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.