NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: Isoliquiritigenin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

integrin, alpha 2

Prostate Cancer

DU-145

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Isoliquiritigenin inhibits cell adhesion, which was related to decreases in integrin-alpha2. The present results indicate that decreases in this adhesion-regulating molecules contribute to ISL-induced decreases in DU145 cell adhesion.Integrins mediate adhesion between cells and their neighboring matrices and transmit important signals regulating cell survival, differentiation and migration.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.