NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: Isoliquiritigenin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

TIMP metallopeptidase inhibitor 1

Prostate Cancer

DU-145

-

-

-

-

Results of Western blot analysis showed that EGF-stimulated secretion of TIMP-1 and ISL inhibited secretion of these proteins regardless of whether the cells were treated with EGF. TIMP-1 preferentially inhibits MMP-9. Increasing evidence indicates a more complex role for TIMP-1 during tumor progression, besides its regulation of MMP-mediated ECM degradation. It has been reported that TIMP-1 mediates cell survival signal transduction pathways via its interaction with CD63/integrin-Beta1 comple.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.