NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Isoliquiritigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
TIMP1TIMP metallopeptidase inhibitor 17076Prostate CancerDU-145----Results of Western blot analysis showed that EGF-stimulated secretion of TIMP-1 and ISL inhibited secretion of these proteins regardless of whether the cells were treated with EGF. TIMP-1 preferentially inhibits MMP-9. Increasing evidence indicates a more complex role for TIMP-1 during tumor progression, besides its regulation of MMP-mediated ECM degradation. It has been reported that TIMP-1 mediates cell survival signal transduction pathways via its interaction with CD63/integrin-Beta1 comple.18824345

 






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