NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Kaempferol-7-O-beta-d-glucoside

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Cervix AdenocarcinomaHeLa----up-regulation of Bax was observed, suggesting an increase of Bax/Bcl-2 ratios might be involved in apoptosis induced by Kaempferol-7-O-beta-d-glucoside18343026
BCL2B-cell CLL/lymphoma 2596Cervix AdenocarcinomaHeLa----Down-regulation of Bcl-2 were observed, suggesting an increase of Bax/Bcl-2 ratios might be involved in apoptosis induced by Kaempferol-7-O-beta-d-glucoside18343026
CCNB1cyclin B1891Cervix AdenocarcinomaHeLa----Western blot result showed decrease in the level of Cyclin B1 and Cdk1 protein at 12 and 24 h post-treatment, which suggested that down-regulation of the expression of G2 phase regulating proteins might contribute to KG-mediated cell cycle arrest in HeLa cells18343026
CDK1cyclin-dependent kinase 1983Cervix AdenocarcinomaHeLa----Western blot result showed decrease in the level of Cyclin B1 and Cdk1 protein at 12 and 24 h post-treatment, which suggested that down-regulation of the expression of G2 phase regulating proteins might contribute to KG-mediated cell cycle arrest in HeLa cells18343026

 






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