NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Limonin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Colon CancerSW-480----Expression of Bax was 3.0 and 5.0-fold higher with limonin (100 µM) treatment for 24 and 48 h, respectively, compared to control. The ratio of Bcl2 to Bax was significantly lower (up to 9-fold), after 48 h of incubation with limonin.21338095
BCL2B-cell CLL/lymphoma 2596Colon CancerSW-480----Reduced expression of antiapoptotic bcl2 was ob-served in cells incubated with limonin. Expression of Bcl2 was depleted by 30% in the case of limonin after 48 h.The ratio of Bcl2 to Bax was significantly lower (up to 9-fold), after 48 h of incubation with limoni.21338095
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon CancerSW-480----limonin resulted in significant (P< 0.05) activation of caspase-3 by 3.5 fold higher compared to control, after 48 h of incubation. These results clearly suggest the involvement of caspase mediated apoptosis to inhibit the proliferation of colon cancer cells by limonoid.21338095
CYCScytochrome c54205Colon CancerSW-480----The content of cytosolic cytochrome c increased significantly (p < 0.05) by 11.6% following incubation with limonin and LG for 48 h, indicating the involvement of intrinsic apoptosis to induce cytotoxicity.21338095

 






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