NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Myricetin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Skin CarcinomaSKH-1----Myricetin-mediated inactivation of Akt in the UVB response plays a role in regulating UVB-induced carcinogenesis21793847
JAK1Janus kinase 13716Murine epidermalJB6----Myricetin inhibited the phosphorylation of JAK1 and their data indicate that myricetin might directly target JAK1 to block cell transformation in mouse JB6 cells.18995957
MAP2K4mitogen-activated protein kinase kinase 46416Skin CarcinomaSKH-1----Myricetin can bind with MKK4 directly and that it attenuated tumor necrosis factor-alpha (TNF-a)-induced JNK and ERK phosphorylation, AP-1 activation, and VEGFexpression. Myricetin fits easily into the ATP-binding site of MKK4, located between the N- and C-lobes of the kinase domain. 21793847
RAF1v-raf-1 murine leukemia viral oncogene homolog 15894Skin CarcinomaSKH-1----Raf kinase is a critical target for myricetin in inhibiting the UVB-induced formation of wrinkles and suppression of type I procollagen and collagen levels in mouse skin.21793847
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774Murine epidermalJB6----Myricetin inhibited DNA- binding and transcriptional activity of STAT3. Furthermore, myricetin inhibited the phosphorylation of STAT3 at Tyr705 and Ser72.18995957
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-55±8 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-59±6 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415

 






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