NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
a

Compound: Natsudaidain

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
COX-2cytochrome c oxidase subunit II4513Basophilic leukemiaRBL-2H3----The mRNA levels of cyclooxygenase-2 in A23187-stimulated RBL-2H3 cells treated with natsudaidain were markedly decreased (reduction rate is 18.6, 45.6 and58.1% at5, 25 and50µM, respectively) and hence natsudaidain inhibits COX-2 protein.19126304
MAPK1mitogen-activated protein kinase 15594Basophilic leukemiaRBL-2H3----Natsudaidain treatment significantly decreased phosphorylated-p38 MAPK protein levels immediately after stimulatio.19126304
TNFtumor necrosis factor7124Basophilic leukemiaRBL-2H3----Natsudaidain treatment dose-dependently decreased the TNF- alpha protein levels in culture supernatant.Expression levels of TNF-alpha mRNA were also dose-dependently reduce.19126304

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.