NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
a

Compound: Oleandrin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
FGF2fibroblast growth factor 22247Prostate CancerDU-145----Oleandrin (0.1 ng/mL) produced a 45.7% inhibition of FGF-2 release from PC3 cells and a 49.9% inhibition from DU145 cells.11448457
FGF2fibroblast growth factor 22247Prostate CancerPC-3----Oleandrin (0.1 ng/mL) produced a 45.7% inhibition of FGF-2 release from PC3 cells and a 49.9% inhibition from DU145 cells.11448457
JUNjun proto-oncogene3725LeukemiaU-937----The activation of AP-1 was completely inhibited by oleandrin in a concentration-dependent manner,with maximum suppression occurring at 0.50 mg/ml.10919658
MAPK8mitogen-activated protein kinase 85599LeukemiaU-937----A 1 mg/ml concentration of oleandrin inhibited most of the JNK induced10919658
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Cervix AdenocarcinomaHeLa----Oleandrin blocked tumor necrosis factor (TNF)-induced activation of NF-kB in a concentration- and time-dependent manner.The TNF-induced NF-kB activation cascade involving TNF receptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kB-inducing kinase/IkBa kinase was interrupted at the TNF receptor-associated factor 2 and NF-kB-inducing kinase sites by oleandrin, thus suppressing NF-kB reporter gene expression.10919658
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790LeukemiaU-937----Oleandrin blocked tumor necrosis factor (TNF)-induced activation of NF-kB in a concentration- and time-dependent manner.The TNF-induced NF-kB activation cascade involving TNF receptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kB-inducing kinase/IkBa kinase was interrupted at the TNF receptor-associated factor 2 and NF-kB-inducing kinase sites by oleandrin, thus suppressing NF-kB reporter gene expression.10919658
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Ovarian CancerCaOV3----Oleandrin blocked tumor necrosis factor (TNF)-induced activation of NF-kB in a concentration- and time-dependent manner.The TNF-induced NF-kB activation cascade involving TNF receptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kB-inducing kinase/IkBa kinase was interrupted at the TNF receptor-associated factor 2 and NF-kB-inducing kinase sites by oleandrin, thus suppressing NF-kB reporter gene expression.10919658
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790T cell leukemiaJurkat T----Oleandrin blocked tumor necrosis factor (TNF)-induced activation of NF-kB in a concentration- and time-dependent manner.The TNF-induced NF-kB activation cascade involving TNF receptor 1/TNF receptor-associated death domain/TNF receptor-associated factor 2/NF-kB-inducing kinase/IkBa kinase was interrupted at the TNF receptor-associated factor 2 and NF-kB-inducing kinase sites by oleandrin, thus suppressing NF-kB reporter gene expression.10919658

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.