NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Pinocembrin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP9caspase 9, apoptosis-related cysteine peptidase842Colon cancerHCT-116----Caspase-9 was cleaved to its cleavage fragment (37 kDa) after 48 h of pinocembrin treatment.Pinocembrin-induced caspase-9 processing is subsequent to loss of mitochondrial membrane permeabilization and release of cytochrome c into cytosol, indicating a possible role for classical mitochondrial apoptotic signaling. Caspase-9 inhibitor reduced the chromatin condensation to 18%, compared to 30% in DMSO control.17186548

 






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