NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: Rosmanol

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

CASP3

caspase 3, apoptosis-related cysteine peptidase

836

Colon Cancer

COLO-205

-

-

-

-

the band of pro-caspase-3 protein after 24 h of 50 lM rosmanol treatment is less than that of the control group, indicating the cleavage of procaspase-3 to active caspase-3. Furthermore, the lower expression of cleaved caspase-3 at 24 h is likely due to degradation secondary to apoptosis. The result showed a gradual decrease in the levels of pro-caspase-9 and pro-caspase-3 and a corresponding increase in the cleavage of pro-caspase-9 and pro-caspase-3, indicating that both caspases were activated after rosmanol treatment.

21112365

CASP3

caspase 3, apoptosis-related cysteine peptidase

836

Colon Cancer

COLO-205

-

-

-

-

the expression of both pro-caspase-8 and Bid decreased at 6 h after rosmanol treatment and the trend of reduction continued from 6 to 24 h.

21112365

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.