NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Solamargine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Human Lung CarcinomaH69----The anti-apoptotic Bcl-2 genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
BCL2B-cell CLL/lymphoma 2596Large-cell carcinomaH-661----The anti-apoptotic Bcl-2 genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
BCL2B-cell CLL/lymphoma 2596Lung squamus carcinomaH520----The anti-apoptotic Bcl-2 genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
BCL2B-cell CLL/lymphoma 2596Papillary adenocarcinomaH-441----The anti-apoptotic Bcl-2 genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
BCL2L1BCL2-like 1598Human Lung CarcinomaH69----The anti-apoptotic Bcl-x(L) genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
BCL2L1BCL2-like 1598Large-cell carcinomaH-661----The anti-apoptotic Bcl-x(L) genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
BCL2L1BCL2-like 1598Lung squamus carcinomaH520----The anti-apoptotic Bcl-x(L) genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
BCL2L1BCL2-like 1598Papillary adenocarcinomaH-441----The anti-apoptotic Bcl-x(L) genes were downregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
CASP3caspase 3, apoptosis-related cysteine peptidase836Human Lung CarcinomaH69----Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp).15527763
CASP3caspase 3, apoptosis-related cysteine peptidase836Large-cell carcinomaH-661----Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp).15527763
CASP3caspase 3, apoptosis-related cysteine peptidase836Lung squamus carcinomaH520----Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp).15527763
CASP3caspase 3, apoptosis-related cysteine peptidase836Papillary adenocarcinomaH-441----Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp).15527763
CYCScytochrome c54205Human Lung CarcinomaH69----Solamargine caused the release of cytochrome c from mitochondria.15527763
CYCScytochrome c54205Large-cell carcinomaH-661----Solamargine caused the release of cytochrome c from mitochondria.15527763
CYCScytochrome c54205Lung squamus carcinomaH520----Solamargine caused the release of cytochrome c from mitochondria.15527763
CYCScytochrome c54205Papillary adenocarcinomaH-441----Solamargine caused the release of cytochrome c from mitochondria.15527763
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 22064Lung adenocarcinomaA549----The ratios of HER2 to b-actin gene expressions revealed that cells treated with SM exhibited a level of significance of HER2 expression lower than the untreated control.17639997
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 22064Papillary adenocarcinomaH-441----The ratios of HER2 to b-actin gene expressions revealed that cells treated with SM exhibited a level of significance of HER2 expression lower than the untreated control.17639997
FADDFas (TNFRSF6)-associated via death domain8772Human Lung CarcinomaH69----The apoptotic FADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
FADDFas (TNFRSF6)-associated via death domain8772Large-cell carcinomaH-661----The apoptotic FADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
FADDFas (TNFRSF6)-associated via death domain8772Lung squamus carcinomaH520----The apoptotic FADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
FADDFas (TNFRSF6)-associated via death domain8772Papillary adenocarcinomaH-441----The apoptotic FADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
FasTNF receptor superfamily, member 6355Lung adenocarcinomaA549----Adding Solamargine up-regulated the gene expression of Fas in A549 cells according to RT-PCR.17639997
FasTNF receptor superfamily, member 6355Papillary adenocarcinomaH-441----Adding Solamargine up-regulated the gene expression of Fas in H441 cells according to RT-PCR.17639997
LTAlymphotoxin alpha (TNF superfamily, member 1)4049Human Lung CarcinomaH69----Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF beta15527763
LTAlymphotoxin alpha (TNF superfamily, member 1)4049Large-cell carcinomaH-661----Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF beta15527763
LTAlymphotoxin alpha (TNF superfamily, member 1)4049Lung squamus carcinomaH520----Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF beta15527763
LTAlymphotoxin alpha (TNF superfamily, member 1)4049Papillary adenocarcinomaH-441----Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF beta15527763
TNFtumor necrosis factor7124Human Lung CarcinomaH69----Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF-alpha15527763
TNFtumor necrosis factor7124Large-cell carcinomaH-661----Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF-alpha15527763
TNFtumor necrosis factor7124Lung squamus carcinomaH520----Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF-alpha15527763
TNFtumor necrosis factor7124Papillary adenocarcinomaH-441----Solamargine increased the expression of TNFRs and consequently improved the susceptibility of lung cancer cells to TNF-alpha15527763
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A7132HepatomaHep-3B----Results revealed that solamargine could elevate the gene and protein expressions of TNFR-I of Hep3B cells.11108802
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B7133HepatomaHep-3B----Results revealed that solamargine could elevate the gene and protein expressions of TNFR-II of Hep3B cells.11108802
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Lung adenocarcinomaA549----Solamargine down-regulated the gene expression of TOP2A in A549 and H441 cells, as determined by comparison with the control.17639997
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Papillary adenocarcinomaH-441----Solamargine down-regulated the gene expression of TOP2A in A549 and H441 cells, as determined by comparison with the control.17639997
TRADDTNFRSF1A-associated via death domain8717Human Lung CarcinomaH69----The apoptotic TRADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
TRADDTNFRSF1A-associated via death domain8717Large-cell carcinomaH-661----The apoptotic TRADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
TRADDTNFRSF1A-associated via death domain8717Lung squamus carcinomaH520----The apoptotic TRADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763
TRADDTNFRSF1A-associated via death domain8717Papillary adenocarcinomaH-441----The apoptotic TRADD genes was upregulated after the IC50 concentration of Solamargine treatment for 16 h.15527763

 






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