NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: Solamargine

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

caspase 3, apoptosis-related cysteine peptidase

Human Lung Carcinoma

H69

-

-

-

-

Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp).

caspase 3, apoptosis-related cysteine peptidase

Large-cell carcinoma

H-661

-

-

-

-

Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp).

caspase 3, apoptosis-related cysteine peptidase

Lung squamus carcinoma

H520

-

-

-

-

Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp).

caspase 3, apoptosis-related cysteine peptidase

Papillary adenocarcinoma

H-441

-

-

-

-

Induction of apoptosis by Solamargine(SM) in lung cancers was accompanied by significant increase in caspase-3 activity . At the late phase of apoptosis, the activation of caspase-3 will cleave DNA into oligonucleosomal fragments (180-200 bp).

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.