NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Thymoquinone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Colon cancerHCT-116----Thymoquinone triggers apoptosis in a dose- and time-dependent manner. The apoptotic effects of TQ are modulated by Bcl-2 protein and are linked to and dependent on p53. Our data support the potential for using the agent TQ for the treatment of colon cancer.15375533
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Colon cancerHCT-116----Thymoquinone triggers apoptosis in a dose- and time-dependent manner. Apoptosis induction by TQ was associated with a 2.5-4.5-fold increase in mRNA expression of p53 and the downstream p53 target gene, p21WAF1. Simultaneously, we found a marked increase in p53 and p21WAF1 protein levels but a significant inhibition of anti-apoptotic Bcl-2 protei.15375533
TP53tumor protein p537157Colon cancerHCT-116----Thymoquinone triggers apoptosis in a dose- and time-dependent manner. Apoptosis induction by TQ was associated with a 2.5-4.5-fold increase in mRNA expression of p53 and the downstream p53 target gene, p21WAF1. Simultaneously, we found a marked increase in p53 and p21WAF1 protein levels but a significant inhibition of anti-apoptotic Bcl-2 protei.15375533

 






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