NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
a

Compound: Xerophilusin B

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon9641Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----The effects were tested of the ent-kauranes on NF-kB activation and the translocation of p65, as well as on IkB degradation. NF-kappaB activation was clearly reduced in the presence of test compounds 1-3 (1 µM), whereas compound 4 had no effect . In contrast, p65 translocation from the cytoplasm to the nucleus was inhibited by all four test compounds. Compound 4 again exhibited a different behavior in that its effect was dependent on the amount of LPS stimulation time. Finally, all four ent-kauranes tested were found to inhibit the LPSinduced degradation of IkB .19719246

 






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