NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Z-Guggulsterone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CDK6cyclin-dependent kinase 61021Head and neck squamous cell carcinomaUM-22b----In UM-22b cells, expression levels of proteins that promote the transition from the G1 to the S phase of the cell cycle, including CDK6 which is a target gene for both STAT3 and NFkappaB, showed modest decreases following 16 h of guggulsterone (10 microM) treatment19762335

 






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