NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: Zhankuic acid C

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

B-cell CLL/lymphoma 2

Colon Cancer

HT-29

-

-

-

-

nuclear full length PARP was decreased, and the cleaved form of PARP in the nuclei was significantly increased after 48 h of treatment .Similar results were obtained for the inhibition of Bcl-2 and pro-caspase-3 expression. During the apoptosis, PARP has been reported to be proteolyzed directly by active caspase-3, resulting in the inactivation of PARP for DNA repair.

caspase 3, apoptosis-related cysteine peptidase

Colon Cancer

HT-29

-

-

-

-

nuclear full length PARP was decreased, and the cleaved form of PARP in the nuclei was significantly increased after 48 h of treatment .Similar results were obtained for the inhibition of Bcl-2 and pro-caspase-3 expression. During the apoptosis, PARP has been reported to be proteolyzed directly by active caspase-3, resulting in the inactivation of PARP for DNA repair.

poly (ADP-ribose) polymerase 1

Colon Cancer

HT-29

-

-

-

-

nuclear full length PARP was decreased, and the cleaved form of PARP in the nuclei was significantly increased after 48 h of treatment .Similar results were obtained for the inhibition of Bcl-2 and pro-caspase-3 expression. During the apoptosis, PARP has been reported to be proteolyzed directly by active caspase-3, resulting in the inactivation of PARP for DNA repair.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.