NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
a

Compound: Alpinumisoflavone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Human Lung TumorH210833 µM (24h)---Alpinumisoflavone treatment increased the sub-G1 population of lung tumor cells and increased their caspase 3 activity, indicating that AIF induces apoptosis.21415528
CASP7caspase 7, apoptosis-related cysteine peptidase840Human Lung TumorH210833 µM (24h)---Alpinumisoflavone treatment increased the sub-G1 population of lung tumor cells and increased their caspase 7 activity, indicating that AIF induces apoptosis.21415528
JUNjun proto-oncogene3725Human Lung TumorH210833 µM (24h)---Western blot analysis showed that AIF interferes with the phosphorylation of ERK and MEK kinase. In addition, AIF reduced the level of c-Jun expression suggesting that AIF is involved in the inhibition of ERK/MAPK pathway.21415528
MAP2K1mitogen-activated protein kinase kinase 15604Human Lung TumorH210833 µM (24h)---Western blot analysis showed that AIF interferes with the phosphorylation of ERK and MEK kinase. In addition, AIF reduced the level of c-Jun expression suggesting that AIF is involved in the inhibition of ERK/MAPK pathway.21415528
MAPK1mitogen-activated protein kinase 15594Human Lung TumorH210833 µM (24h)---Western blot analysis showed that AIF interferes with the phosphorylation of ERK and MEK kinase. In addition, AIF reduced the level of c-Jun expression suggesting that AIF is involved in the inhibition of ERK/MAPK pathway.21415528
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792Human Lung TumorH210833 µM (24h)---Data showed that AIF interferes with the nuclear transport of NF-kappaB by inhibiting the degradation of IkBalpha.21415528
NOS2nitric oxide synthase 2, inducible4843Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.715.97 µM---Alpinumisoflavone represses NO production in a dose-dependent manner, with an IC50 of 15.97 mM.21415528

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.