NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Capsaicin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792Prostate CancerPC-3----Capsaicin inhibited the TNF-alpha-induced IkBalpha degradation in the cytoplasm, thus preventing the TNF-alpha-dependent translocation of NF-kappaB to the nucleus. Furthermore, IkBalpha protein levels increased in PC-3 cells; capsaicin either stabilizes the IkBalpha and/or inhibits the IKK activity, resulting in the inhibition of IkBalpha degradation. 16540674

 






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