NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Hispidulin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Human Glioblastoma MultiformeGBM890140 µM---Hispidulin subsequently enhanced the expression level of p21, resulting in cell-cycle arrest in GBM cells.20734985
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Human Glioblastoma MultiformeGBM840160 µM---Hispidulin subsequently enhanced the expression level of p21, resulting in cell-cycle arrest in GBM cells.20734985
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit5564Human Glioblastoma MultiformeGBM890140 µM---AMPK is activated by hispidulin in GBMcells. When this occurs, a key enzyme involved in protein synthesis, mTOR, is inhibited. In addition, the activity and/or expression of lipogenic enzymes, such as FASN and ACC, are decreased.20734985
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit5564Human Glioblastoma MultiformeGBM840160 µM---AMPK is activated by hispidulin in GBMcells. When this occurs, a key enzyme involved in protein synthesis, mTOR, is inhibited. In addition, the activity and/or expression of lipogenic enzymes, such as FASN and ACC, are decreased.20734985
TP53tumor protein p537157Human Glioblastoma MultiformeGBM890140 µM---Hispidulin increased the expression level of p53 resulting in cell-cycle arrest in GBM cells.20734985
TP53tumor protein p537157Human Glioblastoma MultiformeGBM840160 µM---Hispidulin increased the expression level of p53 resulting in cell-cycle arrest in GBM cells.20734985

 






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