NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

a

Compound: Hispidulin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

PRKAB1

protein kinase, AMP-activated, beta 1 non-catalytic subunit

5564

Human Glioblastoma Multiforme

GBM8901

40 µM

-

-

-

AMPK is activated by hispidulin in GBMcells. When this occurs, a key enzyme involved in protein synthesis, mTOR, is inhibited. In addition, the activity and/or expression of lipogenic enzymes, such as FASN and ACC, are decreased.

20734985

PRKAB1

protein kinase, AMP-activated, beta 1 non-catalytic subunit

5564

Human Glioblastoma Multiforme

GBM8401

60 µM

-

-

-

AMPK is activated by hispidulin in GBMcells. When this occurs, a key enzyme involved in protein synthesis, mTOR, is inhibited. In addition, the activity and/or expression of lipogenic enzymes, such as FASN and ACC, are decreased.

20734985

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.