NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase
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Compound: Purpurin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CYP1A1cytochrome P4501543------Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Marker enzyme activities demonstrated clearly that induction by purpurin was nonspecific. CYP1A1 was very markedly induced12744663
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 21544------Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Marker enzyme activities demonstrated clearly that induction by purpurin was nonspecific. CYP1A2 was very markedly induced12744663
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 61555------Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Marker enzyme activities demonstrated clearly that induction by purpurin was nonspecific. CYP2B was very markedly induced12744663
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 81558------Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Purpurin treatment was responsible for dose-dependent induction of cytochrome P450 12744663
PORP450 (cytochrome) oxidoreductase5447------Testing of compound was performed in-vivo in male C57bl6 mice after a single dose of the heterocyclic amine dietary carcinogen Trp-P-2. Purpurin treatment was responsible for dose-dependent induction of NADPH cytochrome P450 reductase12744663

 






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