Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search areID | Sequence | Name | Nature of peptide or cargo | Assay | Tissue permeability | Tissue Sample | PUBMED ID |
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1019 | KETWWETWWTEWSQP KKKRKV | Pep-1 | Cell penetrating peptide | In vivo imaging | Significant permeability of the peptide can be seen in in vivo images | Mouse skin cells | 23601371 |
1122 | GIGKFLKKAKKFG KAFVKILKK | Pexiganan | Antimicrobial, Diabetic Foot Ulcers | Wound healing, infection progression, and the number of amputations required were calculated statistically | Clinical improvement rates were (85%–90%), Overall microbiological eradication rates (42%–47%) | Diabetic Foot Ulcers | 18990064 |
1127 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Franz diffusion cell | The results suggest that positively charged magainin facilitated transdermal transport of negatively charged fluorescein due to electrostatic attraction at pH 7.4 and results in 35 fold increase in the permeation of maganine by the NLS control formulation (i.e., from an average of 0.037μg to 1.302 μg of fluorescein), but as the attraction decreased with increasing pH, the skin permeability enhancement decreased as well | Human cadaver skin | 18601987 |
1128 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Franz diffusion cell | The results suggest that positively charged magainin facilitated transdermal transport of positively charged granisetron due to electrostatic attraction at pH 10 and results in 92–fold increase in the permeation of magnine (i.e., from and average of 2.23 μg to 205.55 μg of granisetron), but as the attraction decreased with decreasing pH, the skin permeability enhancement decreased as well | Human cadaver skin | 18601987 |
1129 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Multi-photon excitation microscopy | The increase in permeation of fluorescein Faciliated by magnine can be seen the the microscopic images | Human cadaver skin | 18601987 |
1130 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Multi-photon excitation microscopy | The increase in permeation of granisetron faciliated by magnine can be seen the the microscopic images | Human cadaver skin | 18601987 |
1139 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Franz cell system, Multi-photon microscopy | Skin permeability 1.5x 103cm/h in presence of chemical enhancer,C o-administration of magainin and NLS-ethanol led to extensive magainin penetration throughout the stratum corneum which could be easily visualised in the microscopic images | Human cadaver skin | 17628164 |
1198 | RQIKIWFQNRRMKWK KSIINFEKL | ANTP-OVA8 (OVA257–264 linked to Antennapedia transduction sequence) | ANTP-OVA8 enhances the delivery of the antigen through the skin and promotes the generation of CTL | Histochemical staining | Penetration of the antigen across skin surface with strong staining of all skin tissue layers. The penetration was rapid and detectable at 30 min | Tape-stripped ears of mice | 15121311 |
1289 | GrGDIPASSKGGGGS rLLLLLLr | RGD peptide matrix | Acts as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | At each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 57% (32 patients) | Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | 8080985 |
1290 | GrGDIPASSKGGGGS rLLLLLLr | RGD peptide matrix | Acts as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | At each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 55% (23 patients) | Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | 8080985 |
1291 | GrGDIPASSKGGGGS rLLLLLLr | RGD peptide matrix | Acts as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | At each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 54% (21 patients) | Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | 8080985 |
1292 | GrGDIPASSKGGGGS rLLLLLLr | RGD peptide matrix | Acts as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | At each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 56% (20 patients) | Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | 8080985 |
1293 | GrGDIPASSKGGGGS rLLLLLLr | RGD peptide matrix | Acts as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | At each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 58% (16 patients) | Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | 8080985 |
1294 | GrGDIPASSKGGGGS rLLLLLLr | RGD peptide matrix | Acts as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | At each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Mean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 61% (14 patients) | Patients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | 8080985 |
1357 | AGYKPDEGKRGDACE GDSGGPFV | TRAP-508 | Thromboplastin activation product of prothrombin with high clotting and esterase activity. | Histological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength. | 41% increase in breaking strength, P< 0.001, at 500 pmol/cm, histology demonstrated a more advanced state of healing, ratio test/saline control of incisional breaking strength is 1.37±0.39 | A single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose. | 1373740 |
1358 | AGYKPDEGKRGDACE GDSGGPFV | TRAP-508b | Thromboplastin activation product of prothrombin with high clotting and esterase activity. | Histological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength. | Increased breaking strength > 80% over control values at day 7, P<0.001 | A single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose. | 1373740 |
1359 | AGYKPDEGKRGDACE GDSGGPFV | TRAP-508b | Thromboplastin activation product of prothrombin with high clotting and esterase activity. | Histological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength. | 39% increase over control breaking strength(P < 0.001) | A single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose. | 1373740 |
1360 | AGYKPDEGKRGDACE GDSGGPFV | TRAP-508b | Thromboplastin activation product of prothrombin with high clotting and esterase activity. | Histological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength. | 18% increase over control breaking strength (P< 0.002) | A single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose. | 1373740 |
1404 | AGYKPDEGKRGDACE GDSGGPFV | TRAP 508 (Thrombin receptor-activating peptide) | Mimics many effects of thrombin | Angiography and histology | After 7 days, incisions treated with a single application of alpha-thrombin(10 pmol or 0.3310 micro gram/cm of incision) showed a 26% increase in breaking strength over those treated with PBS alone with a P value of <0.013. But, a single application of TRAP-508 worked even better than thrombin increasing breaking strength 41% over controls (P<0.001, at 500 pmol/cm). | Mice skin | 1373740 |
1434 | AEKKDEGPYRMEHFR WGSPPKD | β-MSH (β-Melanocyte-stimulating hormone) | MSH stimulate the production and release of melanin (a process referred to as melanogenesis) by melanocytes in skin and hair. MSH actions in the brain have effects on appetite and sexual arousal. | Osmolarity and tear volume measurements | Osmolarity measurements: t=0 min., β-MSH/Buffer=310/311mOsm/l; t=6 min., β-MSH/Buffer=301.5/306mOsm/l; t=16 min., β-MSH/Buffer=306/308mOsm/l; Volume measurement: β-MSH/Buffer= 14µl/56.1µl | Eyes of male and female New Zealand white rabbits with closed lacrimal gland excretory duct | 2365569 |
1545 | GRKKRRQRRRPPQ-P DALKSRTLR | μ-N2-10-2 (HIV-Nμ) (μ-calpain peptide ) | Not mentioned | Immunofluorescence,TUNEL staining | TUNEL positive cells reduced by 50% in HIV-nu traeted retinas | cornea of the eye | 22885154 |