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Human Papillomaviruses

Human Papillomaviruses (HPVs) are the small circular double-stranded DNA viruses.

It belongs to the papillomaviridae family, taxonomically classified into distinct genera: Alpha, Beta, Gamma, Mupa and Nupa.

These are further classified into distinct subgroups: high-risk and low risk HPVs.


HVPbase: A Comprehensive Viral Resource for Papillomavirus and Biomarkers Study


Oncogenic HPV16 genomic Organization HPVbase overview Integration and breakpoints Methylation events miRNAs aberrant expression
Type 16 Type 18 Type 26 Type 31 Type 33 Type 39 Type 45 Type 53 Type 58 Type 59 Type 66 Type 2 Type 7 Type 10 Type 29 Type 77 Type 6b Type 11 Type 13 Type 32 Type 34 Type 43 Type 54 Type 61 Type 70 Type 81 Type 83 Type 84 Type 85 Type 90 Type 91 Type 5 Type 9 Type 17 Type 49 Type 92 Type 96 Type 4 Type 48 Type 50 Type 60 Type 88 Type 95 Type 1 Type 63 Type 41

Reference

Kumar Gupta, A. and Kumar, M. HPVbase- a knowledgebase of viral integrations, methylation patterns and microRNAs aberrant expression: As potential biomarkers for Human papillomaviruses mediated carcinomas. Sci. Rep. 5, 12522; doi: 10.1038/srep12522 (2015).

Scientific Reports      Pubmed

About

High-risk human papillomavirus (HPV) genotypes cause cervical cancer. They are also responsible for other anogenital, and head and neck cancers

Cervical cancer progression highly depend on cellular and viral risk factors

HPVbase is an integrated viral resource and analysis platform for Human Papillomaviruses mediated carcinomas

It comprises different sections for viral and cellular biomarkers

Different biomarkers includes integration and breakpoint events, HPV methylation pattern, and microRNAs (miRNAs) aberrant expression

Highly interactive and user friendly interface

Cervical progression and biomarkers

For more and help...

Bioinformatics Centre (BIC), Institute of Microbial Technology (IMTECH), Council of Scientific and Industrial Research (CSIR)
HPVbase Viral Genomics Website is maintained and hosted by the Dr. Manoj Lab at Bioinformatics Centre, CSIR-IMTECH, Chandigarh.
HPVbase Team 2014. For any query and suggestion, Please Contact us.