This page allows user to cluster cell lines based on their sensitivity towards a drug. We group cell lines for each drug based on their relative sensitivity to reference (highest sensitivity) or inhibition IC50 value in a given range. User can either choose tissue type or all cell lines or can select the cell lines with mutated drug targets. The second column gives the number of cell lines screened against the drug as it is equal to or greater than reference IC50 (lowest of all). Subsequent columns, up to eight, give grouping based on IC50 value equal to or greater than 3, 5, 25, 100 and 250 times of reference IC50. The columns from nine to sixteen shows the group of cell lines having absolute value of IC50 lying in different ranges (R1, R2, R3, R4, R5, R6, R7 and R8). The cell line in groups with lower value are those which are very sensitive to that drug while groups with high IC50 values comprise cell lines having high resistance and are important for study of resistance-mechanism. For more information, please click |
