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This page gives details of CPPsite entry with ID 1831 |
| Primary information | |
|---|---|
| CPPsite ID | 1831 |
| PEPTIDE SEQUENCE | GRKKRRQRRRPPQC |
| PEPTIDE NAME | HIV-1 Tat (48-60) |
| CHIRALITY | L |
| LINEAR/CYCLIC | Linear |
| SOURCE | Protein derived |
| CATEGORY | Cationic |
| SUB CELLULAR LOCALIZATION | Only punctate distribution (vesicles) |
| N-TERMINAL MODIFICATION | Free |
| C-TERMINAL MODIFICATION | Conjugation with Alexa 488 at glycyl cysteine sequence |
| UPTAKE EFFICIENCY | Unknown |
| PROPOSED UPTAKE MECHANISM | Endocytic pathway (Macropinocytosis) |
| INVITRO/INVIVO | In vitro |
| CELL LINE | CHO-K1, HeLa and Jurkat |
| CARGO | Fluorophore (Alexa-488) |
| PMID | 19707187 |
| PATENT | US 20040132970 |
| LENGTH | 14 |
| Secondary Structure | CCTTCCCCCCSSCC |
| SMILES | NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C=O |
| Tertiary Structure (Technique) | View in Jmol OR Download Structure (PEPstrMOD) |