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This page gives details of CPPsite entry with ID 2037
Primary information
CPPsite ID2037
PEPTIDE SEQUENCEAGYLLGKINLKALAALAKKIL
PEPTIDE NAMENF53
CHIRALITYModified
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYAmphipathic
N-TERMINAL MODIFICATIONStearylation
C-TERMINAL MODIFICATIONAmidation
CHEMICAL MODIFICATIONε-NH2 group of Lys7 for subsequent synthesis
UPTAKE EFFICIENCY10-100 fold higher than stearyl-TP10
INVITRO/INVIVOin vitro
CELL LINECHO, HeLa pLuc705, HEK293,U2OS, U87, MEF, U2OSEBNALTD3, Jurkat cells, A20 cells and CHOEBNALT86
CARGONucleic acid (Plasmid DNA, SCO and siRNA)
PMID23357356
PATENTUnknown
LENGTH21
Secondary StructureCCCCCTTSCTHHHHHHHTTTC
SMILESN[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C=O
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)