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This page gives details of CPPsite entry with ID 2129
Primary information
CPPsite ID2129
PEPTIDE SEQUENCEYGRKKRRQRRR
PEPTIDE NAMETAT-gelonin
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
N-TERMINAL MODIFICATIONFree
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYStrong fluorescence signal was observed inside the cells incubated with TAT-gelonin, indicating rapid and efficient transduction of TAT-gelonin mediated by TAT
PROPOSED UPTAKE MECHANISMFluid phase pinocytosis
INVITRO/INVIVOIn vitro and in vivo
CELL LINELS174T and HCT116, MDCK and 293 HEK
In VIVO MODELC57BL/6 mice
CARGOProtein (gelonin)
PMID25204286
PATENTUnknown
LENGTH11
Secondary StructureCCGGGGGTTCC
SMILESN[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
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  (PEPstrMOD)