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This page gives details of CPPsite entry with ID 2320
Primary information
CPPsite ID2320
PEPTIDE SEQUENCERRWWRRWRR
PEPTIDE NAMER6W3
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytoplasm
N-TERMINAL MODIFICATIONBiotinylation
C-TERMINAL MODIFICATIONAmidation
UPTAKE EFFICIENCYHigher than R9, Tat and R6L4
PROPOSED UPTAKE MECHANISMSelectively driven by the presence of GAGs and is likely distinct from macropinocytosis and general endocytosis
INVITRO/INVIVOIn vitro
CELL LINECHO-K1 (WT) and xylose transferase- or GAG-deficient CHO-pgsA745 cells (GAGneg)
CARGOBiotin-gly4
PMID25112713
PATENTUnknown
LENGTH9
Secondary StructureCHHHHTSCC
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
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  (PEPstrMOD)