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This page gives details of CPPsite entry with ID 2457
Primary information
CPPsite ID2457
PEPTIDE SEQUENCEGGVCPRILRRCRRDSDCPGACICRGNGYCGSGSK
PEPTIDE NAMEMCoTI-M5
CHIRALITYL
LINEAR/CYCLICCyclic
SOURCESynthetic
CATEGORYCationic
N-TERMINAL MODIFICATIONConjugation with Alexa Flour 488
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYHigh (compared to native MCoTI-II)
PROPOSED UPTAKE MECHANISMMacropinocytosis, endocytosis
INVITRO/INVIVOIn vitro
CELL LINEHeLa
CARGOFluorophore (Alexa Fluor 488)
PMID24985034
PATENTUnknown
LENGTH34
Secondary StructureCCCCCSCCCBCSSTTTSCTTCEEETTTEEECSCC
SMILESNCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H]3C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C=O)CCCCN)CO)CO)CS[S@@](SC2)C3)Cc2ccc(cc2)O)CC(=O)N)CCCNC(=N)N)CS)[C@H](CC)C)CSSC1)C)CCC)CC(=O)O)CO)CC(=O)O)CCCNC(=N)N)CCCNC(=N)N
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (Homology based)