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This page gives details of CPPsite entry with ID 2718
Primary information
CPPsite ID2718
PEPTIDE SEQUENCECGGGYGRKKRRQRRR
PEPTIDE NAMEAgNP-TAT
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
UPTAKE EFFICIENCYAgNP-TAT showed significant enhancement in killing tumor cells, e.g. up to 24 fold higher compared to its counterpart without TAT-modification
PROPOSED UPTAKE MECHANISMphagocytosis or a passive, nonspecific diffusion pathway through the cell membrane
INVITRO/INVIVOIn vitro and in vivo
CELL LINECaco-2 cells
In VIVO MODELFemale nude mice having B16 melanoma
CARGONanosilver Nanoparticles
PMID22682937
PATENTUnknown
LENGTH15
Secondary StructureCCSSSSTTHHHHTCC
SMILESN[C@@H](CS)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
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  (PEPstrMOD)