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This page gives details of CPPsite entry with ID 2735
Primary information
CPPsite ID2735
PEPTIDE SEQUENCEKRPTMRFRYTWNPMK
PEPTIDE NAME44
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
UPTAKE EFFICIENCYprimary myelogenous leukaemic cells (AML) showed uptake of CPP44, but not of TAT or CPP2 at comparable concentrations, showed poor penetration into normal fibroblasts
INVITRO/INVIVOIn vitro and in vivo
CELL LINEMany Human neoplastic cells including HeLa, Lovo, A549, MCF-7,MKN45,HepG2, LNCap, KPK,U2OS, RC-15,RD-ES,H28,K562,U251,NHDF
In VIVO MODELNOD-SCID mice model of xenograft human tumour cells
CARGOFluorophore (FITC)
PMID22805558
PATENTUnknown
LENGTH15
Secondary StructureCCCCCCCCCCCCTTC
SMILESN[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCC[NH3])C=O
Tertiary Structure
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