Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence AYGRKKRRQRRR |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | AYGRKKRRQRRR |
| CPPsite ID | 2584, 2585, 2590, |
| PEPTIDE NAME | DOX-TAT-LIP, DOX-T7-TAT-LIP, TAT-cysteine peptide |
| CHIRALITY | L, L, L |
| LINEAR/CYCLIC | Linear, Linear, Linear |
| SOURCE | Protein derived, Protein derived, Protein derived |
| CATEGORY | Cationic, Cationic, Cationic |
| SUB CELLULAR LOCALIZATION | Cytosol and Nucleus, Cytosol and Nucleus, NA |
| N-TERMINAL MODIFICATION | Cysteine addition, Cysteine addition, Free |
| C-TERMINAL MODIFICATION | Free, Free, Free |
| CHEMICAL MODIFICATION | NA, NA, NA |
| UPTAKE EFFICIENCY | Higher than those of DOX-LIP, Efficiently internalized, NA |
| PROPOSED UPTAKE MECHANISM | Endocytosis, Macropinocytosis, NA |
| INVITRO/INVIVO | In vitro and in vivo, In vitro and in vivo, In vitro and in vivo |
| CELL LINE | C6 and bEnd.3 cells, C6 and bEnd.3 cells, HepG2, HeLa cell |
| In VIVO MODEL | BALB/c mice, BALB/c mice, HepG2-xenografted nude mice |
| CARGO | Nanaoparticle (Liposome), Small molecule drug (Doxorubicin), Nanoparticle (Liposome), Small molecule drug (Doxorubicin), protein (Transferin), Nanoparticle (Liposomes) |
| PMID | 24893333, 24893333, 24709209 |
| PATENT | Unknown, Unknown, Unknown |
| Tertiary Structure (Technique) | 2584 (PEPstrMOD), 2585 (PEPstrMOD), 2590 (PEPstrMOD), |