Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence CGRKKRRQRRRPPQ |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | CGRKKRRQRRRPPQ |
| CPPsite ID | 2477, 2480, 2481, 2622, |
| PEPTIDE NAME | NTD, n-NTD, C16NTD, Tat |
| CHIRALITY | L, L, L, L |
| LINEAR/CYCLIC | Linear, Linear, Linear, Linear |
| SOURCE | Protein derived, Protein derived, Protein derived, Synthetic |
| CATEGORY | Cationic, Cationic, Cationic, Cationic |
| SUB CELLULAR LOCALIZATION | Lysosome, Lysosome, Lysosome, Vesicles |
| N-TERMINAL MODIFICATION | Acetylation, Acetylation, Palmitoylation, Free |
| C-TERMINAL MODIFICATION | Amidation, Amidation, Amidation, Free |
| CHEMICAL MODIFICATION | Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-)., Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-)., Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-)., NA |
| UPTAKE EFFICIENCY | NTD shows the lower intracellular accumulation concentration, Lower upatake Efficeincy, Showed better uptake efficiency, High |
| PROPOSED UPTAKE MECHANISM | Endocytic pathway, Endocytic pathway, Endocytic pathway, NA |
| INVITRO/INVIVO | In vitro, In vitro, In vitro, In vitro |
| CELL LINE | HepG2, HepG2, HepG2, ARPE-19, CHO wt and CHO pgsB-618 cells |
| In VIVO MODEL | NA, NA, NA, NA |
| CARGO | Small molecule drug (Doxorubicin), Small molecule drug (Doxorubicin), Small molecule drug (Doxorubicin), Fluorophore (Fluorescein) |
| PMID | 24892976, 24892976, 24892976, 22100438 |
| PATENT | Unknown, Unknown, Unknown, Unknown |
| Tertiary Structure (Technique) | 2477 (PEPstrMOD), 2480 (PEPstrMOD), 2481 (PEPstrMOD), 2622 (PEPstrMOD), |