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Details of CPPsite entry with Sequence IRQRRRR
Primary information
PEPTIDE SEQUENCEIRQRRRR
CPPsite ID 2168, 2487,
PEPTIDE NAMEIRQ, IRQ
CHIRALITYL, L
LINEAR/CYCLICLinear, Linear
SOURCESynthetic, Synthetic
CATEGORYCationic, NA
SUB CELLULAR LOCALIZATIONNA, NA
N-TERMINAL MODIFICATIONFree, Free
C-TERMINAL MODIFICATIONFree, Conjugation to solid lipid nanoparticle
CHEMICAL MODIFICATIONCoupling to polyoxyethylene (40) steartae (SA-PEG2000), NA
UPTAKE EFFICIENCYIRQ modified SLNs showed better drug protection ability, Showed significantly higher drug internalization than that of unmodified ones
PROPOSED UPTAKE MECHANISMClathrin- and caveolae-dependent endocytosis, Both clathrin- and caveolae-dependent endocytosis
INVITRO/INVIVOIn vitro and in vivo, In vitro and in vivo
CELL LINECaco-2/HT29-MTX, Caco-2 cells and goblet like HT29-MTX cells
In VIVO MODELMale Sprague-Dawley rats, Male Sprague-Dawley rats
CARGONanoparticle [salmon calcitonin (sCT)-loaded SLNs (Solid Lipid Nanoparticle)], Protein (FITC-sCT), Nanoparticle( SLN)
PMID24968819, 24968819
PATENTUnknown, Unknown
Tertiary Structure
(Technique)		2168 (PEPstrMOD), 2487 (PEPstrMOD),