Details of CPPsite entry with Sequence KCFQWQRNMRKVRGPPVSCIKR |
Primary information | |
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PEPTIDE SEQUENCE | KCFQWQRNMRKVRGPPVSCIKR |
CPPsite ID | 2178, 2179, 2180, 2181, 2182, 2183, 2184, 2185, 2186, 2187, 2188, 2189, 2190, 2191, 1407, 1824, 1825, |
PEPTIDE NAME | hLF WT, hLF W5A, hLF Q6A, hLF M9A, hLF P15A, hLF V12R, hLF R7A, hLF R13A, hLF R7A/V12R, hLF R13A/P15R, hLF +4R, hLF lin+4R, hLF R7, hLF K7, hLF peptide, hLF(38-59) peptide, hLF(38-59) peptide |
CHIRALITY | L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L |
LINEAR/CYCLIC | Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear |
SOURCE | Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived |
CATEGORY | Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Unknown, Unknown, Unknown |
SUB CELLULAR LOCALIZATION | Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Cytosol and Nucleus, Vesicles at low concentartion and cytoplasm and nucleus at high concentart, Vesicles and membrane bound, Vesicles and membrane bound |
N-TERMINAL MODIFICATION | Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with 5(6)-Carboxyfluorescein, Conjugation with fluorescein, Conjugation with fluorescein, Conjugation with fluorescein |
C-TERMINAL MODIFICATION | Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation |
CHEMICAL MODIFICATION | NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA |
UPTAKE EFFICIENCY | High, Lower than hLF Wt, Lower than hLF Wt, Lower than hLF Wt, Equal to hLF Wt, Equal to hLF Wt, Lower than hLF Wt, Equal to hLF Wt, Equal to hLF Wt, Lower than hLF Wt, Higher than hLF Wt, Higher than hLF Wt, Equal to hLF Wt, Equal to hLF Wt, High and comparable to Tat (48-60) and penetratin, Unknown, Unknown |
PROPOSED UPTAKE MECHANISM | Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Endocytosis and acid sphingomyelinase-dependent induction of nucleation zones (NZ), Unknown, Unknown, Unknown |
INVITRO/INVIVO | In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro |
CELL LINE | HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa, Jurkat E6.1 leukemia cells, Ovcar-3 cells, and Caco-2 cells, HeLa and rat IEC-6 cells, HeLa, MC57 |
In VIVO MODEL | NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA |
CARGO | Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (Fluorescein), Fluorophore (fluorescein), Fluorophore (fluorescein), Fluorophore (fluorescein) |
PMID | 24270856, 24270856, 24270856, 24270856, 24270856, 24270856, 24270856, 24270856, 24270856, 24270856, 24270856, 24270856, 24270856, 24270856, 19858187, 21867915, 21867915 |
PATENT | Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown |
Tertiary Structure (Technique) | 2178 (PEPstrMOD), 2179 (PEPstrMOD), 2180 (PEPstrMOD), 2181 (PEPstrMOD), 2182 (PEPstrMOD), 2183 (PEPstrMOD), 2184 (PEPstrMOD), 2185 (PEPstrMOD), 2186 (PEPstrMOD), 2187 (PEPstrMOD), 2188 (PEPstrMOD), 2189 (PEPstrMOD), 2190 (PEPstrMOD), 2191 (PEPstrMOD), 1407 (PEPstrMOD), 1824 (PEPstrMOD), 1825 (PEPstrMOD), |