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Details of CPPsite entry with Sequence KGRKKRRQRRRPPQ
Primary information
PEPTIDE SEQUENCEKGRKKRRQRRRPPQ
CPPsite ID 2478, 2479,
PEPTIDE NAMEd-NTD, q-NTD
CHIRALITYL, L
LINEAR/CYCLICLinear, Linear
SOURCEProtein derived, Protein derived
CATEGORYCationic, Cationic
SUB CELLULAR LOCALIZATIONLysosome, Lysosome
N-TERMINAL MODIFICATIONAcetylation, Acetylation
C-TERMINAL MODIFICATIONAmidation, Amidation
CHEMICAL MODIFICATIONDoxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-)., Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-).
UPTAKE EFFICIENCYd-NTD is the most potent conjugate against HepG2 human liver cancer cells, q-NTD accumulated most effectively within cancer cells
PROPOSED UPTAKE MECHANISMEndocytic pathway, Endocytic pathway
INVITRO/INVIVOIn vitro, In vitro
CELL LINEHepG2, HepG2
In VIVO MODELNA, NA
CARGOSmall molecule drug (Doxorubicin), Small molecule drug (Doxorubicin)
PMID24892976, 24892976
PATENTUnknown, Unknown
Tertiary Structure
(Technique)		2478 (PEPstrMOD), 2479 (PEPstrMOD),