Details of CPPsite entry with Sequence RRRQRRKKRGYCKCKYGRKKRRQRRR |
Primary information | |
---|---|
PEPTIDE SEQUENCE | RRRQRRKKRGYCKCKYGRKKRRQRRR |
CPPsite ID | 2581, 2583, |
PEPTIDE NAME | dfTAT, nrdfTAT |
CHIRALITY | L, L |
LINEAR/CYCLIC | Linear, Linear |
SOURCE | Protein derived, Protein derived |
CATEGORY | Cationic, Cationic |
SUB CELLULAR LOCALIZATION | Cytosol and Nucleus, Cytosol and Nucleus |
N-TERMINAL MODIFICATION | Extra Cys and Lys added for labeling of TMR and dimerization, bis(maleimido)ethane added |
C-TERMINAL MODIFICATION | Free, Free |
CHEMICAL MODIFICATION | NA, NA |
UPTAKE EFFICIENCY | NA, NA |
PROPOSED UPTAKE MECHANISM | Macropinocytosis, Macropinocytosis |
INVITRO/INVIVO | In vitro, In vitro |
CELL LINE | HeLa, Neuro-2a and HDF cells, HeLa, Neuro-2a and HDF cells |
In VIVO MODEL | NA, NA |
CARGO | Protein (eGFP), Fluorophore (TMR), Fluorophore (TMR) |
PMID | 24930129, 24930129 |
PATENT | Unknown, Unknown |
Tertiary Structure (Technique) | 2581 (PEPstrMOD), 2583 (PEPstrMOD), |