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Details of CPPsite entry with Sequence RRRRNRTRRNRRRVRGC
Primary information
PEPTIDE SEQUENCERRRRNRTRRNRRRVRGC
CPPsite ID 1396, 1833,
PEPTIDE NAMEFHV coat (35-49), FHV coat (35-49)
CHIRALITYL, L
LINEAR/CYCLICLinear, Linear
SOURCEProtein derived, Protein derived
CATEGORYCationic, Cationic
SUB CELLULAR LOCALIZATIONCytoplasm and nucleus, Punctate distribution (vesicles) with diffuse flurescence in cytosole and
N-TERMINAL MODIFICATIONFree, Free
C-TERMINAL MODIFICATIONConjugation with fluorescein by C-terminal Gly Cys amide, Conjugation with Alexa 488 at glycyl cysteine sequence
CHEMICAL MODIFICATIONNA, NA
UPTAKE EFFICIENCYComparable with that of the Tat-(48-60) peptide, 2.7-6.4 times more than the Rev peptide
PROPOSED UPTAKE MECHANISMNon-endocytic pathway, Endocytic pathway (Macropinocytosis)
INVITRO/INVIVOIn vitro, In vitro
CELL LINERAW 264.7, CHO-K1, HeLa and Jurkat
In VIVO MODELNA, NA
CARGOFluorophore (fluorescein), Fluorophore (Alexa-488)
PMID11084031, 19707187
PATENTUnknown, Unknown
Tertiary Structure
(Technique)		1396 (PEPstrMOD), 1833 (PEPstrMOD),