Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence RRRRRRR |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | RRRRRRR |
| CPPsite ID | 2066, 2307, 2682, 2687, 1033, |
| PEPTIDE NAME | R7, R7, TMR-R7, p53-R7, R7 |
| CHIRALITY | L, L, L, L, L |
| LINEAR/CYCLIC | Linear, Linear, Linear, Linear, Linear |
| SOURCE | Synthetic, Synthetic, Synthetic, Synthetic, Synthetic |
| CATEGORY | Cationic, Cationic, Cationic, Cationic, Cationic |
| SUB CELLULAR LOCALIZATION | Cytosol, Cytoplasm and Nucleus, Cytoplasm, NA, Cytoplasm and nucleus |
| N-TERMINAL MODIFICATION | Free, Free, Conjugation with TMR, Conjugated to p53, Conjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer |
| C-TERMINAL MODIFICATION | Free, Free, NA, NA, Free |
| CHEMICAL MODIFICATION | NA, NA, NA, NA, NA |
| UPTAKE EFFICIENCY | Significantly effective compared to the other poly-arginines, Higher uptake efficiency, NA, NA, High (relative to Tat (49-57)) |
| PROPOSED UPTAKE MECHANISM | NA, Non endocytosis, lipid raft dependent macropinocytosis, NA, Probably non-endocytic pathway |
| INVITRO/INVIVO | In vitro, In vivo, In vitro, In vitro, In vitro |
| CELL LINE | A549, NA, U251-MG, HeLa, HEK293 cells, LNZ308, K562 cells, Primary rat fibroblasts cells and U87 cells, LNZ308 cells, Jurkat |
| In VIVO MODEL | NA, Female and male B6D2F1 mice, NA, NA, NA |
| CARGO | Nucleic acid (pDNA), Protein (ESRRB recombinant protein), Fluorophore (TMR), Protein (p53), Fluorophore (fluorescein) |
| PMID | 23534410, 24693491, 22465335, 22465335, 11087855 |
| PATENT | Unknown, Unknown, Unknown, Unknown, US 6593292 |
| Tertiary Structure (Technique) | 2066 (PEPstrMOD), 2307 (PEPstrMOD), 2682 (PEPstrMOD), 2687 (PEPstrMOD), 1033 (PEPstrMOD), |